Podophyllotoxin 9-O-Glucoside

Podophyllotoxin 9-O-Glucoside - Names and Identifiers

Name	Podophyllotoxin-4-O-glucoside
Synonyms	Podophyllotoxin glucoside Podophyllotoxin 9-O-Glucoside Podophyllotoxin 4-O-glucoside Podophyllotoxin-7-O-glucoside Podophyllotoxin-4-O-glucoside Podophyllotoxin 7'-O-beta-D-glucopyranoside
CAS	16481-54-2

Podophyllotoxin 9-O-Glucoside - Physico-chemical Properties

Molecular Formula	C28H32O13
Molar Mass	576.55
Density	1.55
Melting Point	152-154℃
Boling Point	781.3±60.0 °C(Predicted)
Solubility	Soluble in methanol, ethanol, DMSO and other organic solvents
Appearance	Powder
pKa	12.84±0.70(Predicted)
Storage Condition	2-8℃

Podophyllotoxin 9-O-Glucoside - Reference

Reference

1. Wang Linna, Hu Peiyang, Guangyi. Simultaneous determination of six kinds of podophyllolignans by UPLC-MS/MS and its pharmacokinetics [J]. Journal of Hubei University of Medicine 2017(05):411-417.
2. Zhang Chen, Ning, Yang Guangyi, Wei, Jinbao, et al. Determination of four lignans in Nanfang lotus leaf and dysosma japonica by UPLC-MS/MS [J]. Chinese herbal medicine 2015 38(012):2550-2553.

Podophyllotoxin 9-O-Glucoside - Introduction

Podophyllotoxin-4-O-glucoside (Podophyllotoxin-4-O-glucoside) is a natural product whose chemical structure is a conjugate of podophyllotoxin and glucose molecules. It is mainly found in plants of the family Podophyllaceae, such as Podophyllum peltatum and Chinese Podophyllum hexandrum.

Podophyllotoxin-4-O-glucoside have the following properties:
1. Appearance: white to light yellow crystalline powder;
2. Solubility: soluble in water, slightly soluble in ethanol and chloroform.

Podophyllotoxin-4-O-glucoside has a wide range of uses in the field of medicine:
1. Anticancer activity: widely studied for the treatment of various cancers, such as lung cancer, ovarian cancer and breast cancer;
2. Antiviral Activity: inhibition of hepatitis B virus (HBV) and human immunodeficiency virus (HIV);
3. Immunomodulatory effect: it can regulate the function of the immune system and inhibit the inflammatory response.

The preparation method of Podophyllotoxin-4-O-glucoside is relatively simple, mainly obtained by extraction and purification from podophyllaceae plants. As the extraction method, a solvent method, a microwave-assisted extraction method, an ultrasonic-assisted extraction method, and the like can be used.

Regarding safety information, Podophyllotoxin-4-O-glucoside should be used with caution and under the guidance of a doctor. It is generally considered to be relatively safe in the right amount and used correctly. However, long-term use of large doses may cause some discomfort such as nausea, vomiting and diarrhea. Therefore, consult with a doctor before use and follow the correct usage and dosage. Note that pregnant women, lactating women and children are prohibited.

Last Update：2024-04-09 20:48:19